FORMULATION OF CONTROLLED RELEASE MICRONIZED PRONIOSOME-DERIVED NIOSOMES OF CROMOLYN SODIUM TO BE INHALED THROUGH NEBULIZERS USING BIODEGRADABLE SUCROSE STEARATE D18-11, CHOLESTEROL, STEARYL AMINE IN ADDITION TO SALINE SOLUTION (0.9%) AND SPRAY DRIED LACTOSE POWDER, AIMING AT: 1-CONTROLLING RATE OF DRUG RELEASE AFTER INHALATION SO THAT BIOLOGICAL HALF LIFE (80 MIN.) COULD BE INCREASED, CONSEQUENTLY NUMBER OF DOSES (4 – 6 DAILY) SHOULD BE REDUCED.2-LEVELING THE NEBULIZABLE DRUG FRACTION FROM NIOSOMES TO BE EQUIVALENT TO THAT GENERATED FROM DRUG SOLUTION.3-ESTABLISHING A METHOD THAT MINIMIZES PHYSICAL STABILITY PROBLEMS OF NIOSOMES; INCREASE IN SIZE AND DECREASE IN ENCAPSULATION EFFICIENCY
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