ANDROGEN DEFICIENCY OCCURS WITH DISORDERS THAT DAMAGE THE TESTES, INCLUDING TRAUMATIC OR SURGICAL CASTRATION. THE AIM OF THIS PROJECT IS TO PREPARE TESTOSTERONE PATCHES OF DRUG-IN-ADHESIVE TYPE SUITABLE FOR MANUFACTURE IN THE LOCAL MARKET WITH CHEAP AVAILABLE COMPONENTS. THE USE OF EUDRAGIT E-100 MATRICES WITH THE INCORPORATION OF 5% W/W EUDRAGIT RL-100 SECONDARY POLYMER RESULTED IN INCREASING TESTOSTERONE RELEASE IN ALL THE TESTED ANIMALS. THE PATCHES WERE PREPARED BY FILM CASTING OVER A LAYER OF THE BACKING MEMBRANE USING ISOPROPANOL/ETHYL ACETATE SOLVENT MIXTURE. SPAN 85 WAS USED IN THE SOLVENT MIXTURE ALONG WITH TRIACETIN PLASTICIZER. THE OBTAINED TESTOSTERONE FLUX WAS SATISFACTORY TO GET THE REQUIRED TESTOSTERONE SERUM RESULTS REPORTED FOR THE MANAGEMENT OF MALE HYPOGONADISM
./1114.bmp)
